Turkey Tetrazzini with Wine

Featured in: Everyday Mains

This comforting dish blends tender turkey, sautéed mushrooms, and pasta in a creamy white wine sauce enriched with Parmesan and mozzarella. The mixture is topped with buttery panko breadcrumbs and baked until golden, creating a savory casserole that balances richness and texture. Ideal for turning holiday leftovers into an elegant meal.

The preparation involves cooking pasta al dente, sautéing aromatics and mushrooms, then building the sauce with butter, flour, wine, broth, milk, and cream before combining all ingredients. Baking finishes the dish with a crispy, golden crust, perfect for a satisfying main course.

Updated on Sun, 21 Dec 2025 08:47:00 GMT
Creamy Turkey Tetrazzini with golden crust, tender pasta and turkey, a comforting holiday casserole. Save
Creamy Turkey Tetrazzini with golden crust, tender pasta and turkey, a comforting holiday casserole. | sonicpantry.com

There's something about the way mushrooms smell when they hit hot butter that brings me right back to my aunt's kitchen the week after Thanksgiving. She'd stand at the stove with a glass of wine in one hand, tossing sliced mushrooms around a skillet like it was the easiest thing in the world. I didn't know then that she was transforming leftovers into something people actually looked forward to. Now I do the same thing every year, and it feels like carrying on a conversation we never had to finish.

I made this for a group of friends the day after Christmas once, and no one believed me when I said it was leftovers. Someone asked if I'd roasted a whole new turkey just for the casserole. I didn't correct them right away. There's a quiet pride in watching people go back for seconds of something you almost threw together on autopilot.

Ingredients

  • Cooked turkey: Shredded or diced works equally well, dark meat keeps things moist, but white meat is traditional and just as good if the sauce is creamy enough.
  • Spaghetti or linguine: Don't overcook it, the pasta keeps cooking in the oven and mushy noodles ruin the texture.
  • Cremini or white mushrooms: Slice them thin so they cook fast and soak up all that butter and garlic without releasing too much water.
  • Yellow onion: Finely chopped so it melts into the sauce and adds sweetness without chunks.
  • Garlic: Fresh is best, it blooms in the butter and makes the whole kitchen smell like you know what you're doing.
  • Frozen peas: Optional, but they add little pops of color and sweetness that balance the richness.
  • Unsalted butter: You'll use it twice, once in the sauce and once to toast the panko, so don't skimp.
  • All-purpose flour: This is your thickener, cook it long enough to lose the raw taste but not so long it browns.
  • Whole milk and heavy cream: The combination gives you body without being too heavy or too thin.
  • Parmesan cheese: Use the real stuff, not the dusty kind in a can, it melts better and tastes like actual cheese.
  • Mozzarella or Gruyere: Mozzarella is mild and melty, Gruyere is nutty and fancy, both work beautifully.
  • Dry white wine: Chardonnay is classic, but any dry white you'd drink will do, it deglazes the pan and adds depth.
  • Chicken or turkey broth: Low sodium lets you control the salt, and it reinforces the turkey flavor without overpowering it.
  • Dried thyme: Earthy and subtle, it reminds you this is comfort food with a little elegance.
  • Nutmeg: Just a hint, freshly grated if you can, it makes cream sauces taste like a secret.
  • Kosher salt and black pepper: Taste as you go, the cheese adds salt too.
  • Panko breadcrumbs: They crisp up better than regular breadcrumbs and give you that golden crunchy top everyone fights over.

Instructions

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Prep the oven and dish:
Set your oven to 375°F and grease a 9x13-inch baking dish with butter or cooking spray. This prevents sticking and makes cleanup easier later.
Cook the pasta:
Boil spaghetti in well-salted water until just al dente, it should still have a little bite. Drain it and set aside, don't rinse it or the sauce won't cling.
Saute the aromatics:
Melt 4 tablespoons of butter in a large skillet over medium heat, add the onions and cook for 2 minutes until they soften. Toss in the mushrooms and let them cook until they release their water and start to brown, about 5 minutes, then stir in the garlic and cook just until fragrant.
Make the roux:
Sprinkle the flour over the vegetables and stir constantly for 2 minutes. This cooks out the raw flour taste and sets up your sauce to thicken properly.
Deglaze with wine:
Pour in the white wine and scrape up any browned bits stuck to the bottom of the pan, let it simmer for 2 minutes. Those bits are pure flavor.
Build the sauce:
Whisk in the broth, milk, and cream slowly so no lumps form, bring it to a gentle simmer. Let it cook for 3 to 4 minutes until it thickens just enough to coat the back of a spoon.
Season and finish:
Stir in the thyme, nutmeg, salt, and pepper, then remove the skillet from heat. Taste it now, this is your chance to adjust before everything goes in the oven.
Combine everything:
Add the cooked turkey, peas, and drained pasta to the sauce, tossing until every strand is coated. Fold in 1 cup of Parmesan and 1 cup of mozzarella or Gruyere, the residual heat will start melting them.
Transfer to baking dish:
Pour the whole mixture into your prepared dish and spread it out evenly. It should look creamy and generous.
Top with crunch:
In a small bowl, mix the panko with melted butter and 2 tablespoons of Parmesan, then sprinkle it evenly over the casserole. This layer turns golden and crispy and is non-negotiable.
Bake until bubbly:
Slide the dish into the oven and bake for 25 to 30 minutes, until the top is golden and the edges are bubbling. Let it rest for 10 minutes before serving so the sauce thickens up and doesn't run everywhere.
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One winter, I made this on a Sunday and ate it for lunch all week. By Thursday, I was reheating a bowl at my desk and a coworker asked what smelled so good. I offered her a bite and she stood there with a fork, eyes closed, and said it tasted like someone's grandmother made it. I didn't tell her I'd only learned the recipe a year before.

Serving Suggestions

This pairs beautifully with a crisp green salad dressed in lemon vinaigrette to cut through the richness. A glass of the same Chardonnay you cooked with makes the whole meal feel intentional. If you want to lean into comfort, serve it with garlic bread and call it a night.

Storage and Reheating

Leftovers keep covered in the fridge for up to 4 days and reheat like a dream in the microwave or oven. If you're reheating in the oven, cover it with foil and add a splash of milk to bring the sauce back to life. It also freezes well for up to 3 months, just thaw it overnight in the fridge before baking.

Variations and Swaps

You can absolutely use rotisserie chicken instead of turkey, or even leftover ham if you're feeling adventurous. Swap the pasta for egg noodles or penne if that's what you have. Add sauteed spinach or roasted red peppers to sneak in more vegetables without changing the soul of the dish.

  • Try Gruyere instead of mozzarella for a nuttier, more sophisticated flavor.
  • Use half and half instead of milk and cream if that's easier.
  • Toss in a handful of fresh parsley at the end for color and brightness.
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This photo shows a bubbling Turkey Tetrazzini, a flavorful pasta casserole with roasted turkey and cheese. Pin it
This photo shows a bubbling Turkey Tetrazzini, a flavorful pasta casserole with roasted turkey and cheese. | sonicpantry.com

This is the kind of dish that makes you feel like you've got it together, even when you don't. Serve it warm, with people you love, and let it do the rest.

Frequently Asked Questions

What type of pasta works best for this dish?

Linguine or spaghetti hold the creamy sauce well, providing a perfect texture balance.

Can I use a different protein instead of turkey?

Yes, rotisserie chicken is a great substitute and offers similar flavor and texture.

How do I get a golden crust on top?

Sprinkle a mix of panko breadcrumbs, melted butter, and Parmesan cheese before baking to achieve a crisp, golden topping.

Is using white wine essential in the sauce?

White wine adds brightness and depth; however, low-sodium broth can be used alone if preferred.

Can vegetables be added to enhance this casserole?

Sautéed bell peppers, spinach, or peas can be incorporated for additional flavor and color.

What cheese options complement this dish?

A combination of Parmesan and mozzarella or Gruyère provides creamy richness and a savory bite.

Turkey Tetrazzini with Wine

Elegant casserole featuring turkey, mushrooms, pasta, and a rich white wine sauce baked with a cheese crust.

Prep Time
20 Minutes
Cook Time
35 Minutes
Total Time
55 Minutes

Category: Everyday Mains

Difficulty: Medium

Cuisine: American

Yield: 6 servings

Dietary: None specified

Ingredients

Protein & Pasta

01 3 cups cooked turkey, shredded or diced
02 12 oz spaghetti or linguine

Vegetables

01 8 oz cremini or white mushrooms, sliced
02 1 medium yellow onion, finely chopped
03 2 cloves garlic, minced
04 1 cup frozen peas (optional)

Dairy

01 4 tbsp unsalted butter
02 1/4 cup all-purpose flour
03 2 cups whole milk
04 1/2 cup heavy cream
05 1 cup grated Parmesan cheese
06 1 cup shredded mozzarella or Gruyère cheese

Liquids

01 1/2 cup dry Chardonnay or other dry white wine
02 1 cup low-sodium chicken or turkey broth

Seasonings

01 1/2 tsp dried thyme
02 1/4 tsp freshly grated nutmeg
03 1/2 tsp kosher salt, plus more to taste
04 1/4 tsp black pepper

Topping

01 1/2 cup panko breadcrumbs
02 2 tbsp unsalted butter, melted
03 2 tbsp grated Parmesan cheese

Instructions

Step 01

Prepare Oven and Baking Dish: Preheat oven to 375°F. Lightly grease a 9x13-inch baking dish.

Step 02

Cook Pasta: Boil salted water and cook spaghetti until just al dente. Drain and set aside.

Step 03

Sauté Vegetables: Melt 4 tablespoons butter in a large skillet over medium heat. Sauté onions for 2 minutes, then add mushrooms and cook 5 minutes until softened and lightly browned. Stir in garlic and cook for 1 more minute.

Step 04

Make Roux: Sprinkle flour over vegetables and cook, stirring continuously for 2 minutes.

Step 05

Add Wine: Gradually whisk in white wine, scraping browned bits from pan. Simmer for 2 minutes.

Step 06

Incorporate Broth and Dairy: Whisk in broth, whole milk, and heavy cream until smooth. Simmer until slightly thickened, about 3 to 4 minutes.

Step 07

Season Sauce: Stir in dried thyme, freshly grated nutmeg, kosher salt, and black pepper. Remove from heat.

Step 08

Combine Main Ingredients: Fold in cooked turkey, peas if desired, and drained pasta to the sauce. Mix in Parmesan and mozzarella or Gruyère cheeses.

Step 09

Transfer to Baking Dish: Pour the mixture evenly into the prepared baking dish.

Step 10

Prepare Topping: Combine panko breadcrumbs, melted butter, and Parmesan cheese. Sprinkle evenly over casserole.

Step 11

Bake: Bake uncovered for 25 to 30 minutes until sauce is bubbly and topping is golden brown. Let rest 10 minutes before serving.

Tools You'll Need

  • Large skillet
  • Large pot
  • Whisk
  • 9x13-inch baking dish
  • Mixing bowls

Allergy Information

Please check ingredients for potential allergens and consult a health professional if in doubt.
  • Contains wheat (gluten), milk (dairy), and eggs if using egg pasta.
  • May contain sulphites from wine.

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 520
  • Total Fat: 23 g
  • Total Carbohydrate: 48 g
  • Protein: 29 g