Butternut Squash & Sausage Casserole

Featured in: Everyday Mains

This comforting one-pan bake combines sweet roasted butternut squash with savory Italian sausage, nutty quinoa, and wilted spinach. Seasoned with thyme, sage, and paprika, everything simmers in broth before being topped with mozzarella and Parmesan. The result is a bubbly, golden casserole that's naturally gluten-free and perfect for feeding a crowd on chilly evenings.

Updated on Sat, 07 Feb 2026 11:10:00 GMT
Golden melted mozzarella and Parmesan top this Cozy Butternut Squash & Sausage Casserole, featuring roasted squash cubes and savory Italian sausage. Save
Golden melted mozzarella and Parmesan top this Cozy Butternut Squash & Sausage Casserole, featuring roasted squash cubes and savory Italian sausage. | sonicpantry.com

The first time I made this casserole, it was snowing sideways and my kitchen was the only warm place in the world. I had a butternut squash sitting on my counter that I'd bought on impulse, and some Italian sausage from the farmers market. The way the squash caramelized with the sausage made the whole house smell like autumn decided to move in and stay awhile.

I served this at a small dinner party last November when my friend Sarah was going through a tough divorce. She took three helpings and asked for the recipe before she even finished her first plate. Sometimes food does what words cannot.

Ingredients

  • 1 medium butternut squash: Peel and seed this carefully—those curves can be tricky, and a sharp knife makes all the difference
  • 1 medium onion, diced: Yellow onions work beautifully here, becoming sweet and golden as they cook down
  • 2 cloves garlic, minced: Fresh garlic beats jarred every time—press it right before adding so those oils stay potent
  • 3 cups baby spinach: It looks like a mountain going in, but wilts down into just the right amount of green
  • 1 pound Italian sausage: Sweet gives a classic taste, spicy adds that warmth that lingers—remove the casing before cooking
  • 1 cup cooked quinoa: Make this ahead or use leftover—the nutty flavor pairs perfectly with the squash
  • 1 cup shredded mozzarella: Buy it shredded or grate it yourself fresh—that melt factor matters
  • ½ cup grated Parmesan: The salty punch here balances the sweetness of everything else
  • 2 tablespoons olive oil: Use a decent one since you are cooking at medium heat
  • 1 teaspoon dried thyme: Earthy and warm, thyme belongs with squash like they were made for each other
  • 1 teaspoon dried sage: This is the secret ingredient that makes it taste like grandmother's kitchen
  • 1 teaspoon paprika: Smoked paprika adds depth, regular adds color—either works
  • Salt and pepper: Taste as you go, especially since the sausage and Parmesan bring their own salt
  • 1 cup chicken or vegetable broth: This creates a little sauce as everything bakes together

Instructions

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Get your oven ready:
Preheat to 375°F and grease a 9x13 baking dish—do this first so you are not scrambling later when everything is ready to go in
Start the aromatics:
Heat olive oil in a large skillet over medium heat, add diced onion and cook about 5 minutes until it turns translucent and smells sweet
Add the garlic:
Throw in minced garlic for just one minute—you want it fragrant, not browned or bitter
Brown the sausage:
Crank up the heat slightly, add the sausage and break it apart with a wooden spoon, cooking 7 to 10 minutes until it is fully browned and sizzling
Bring in the squash:
Add those cubed pieces along with thyme, sage, paprika, salt and pepper, stirring occasionally for 5 to 7 minutes as the squash begins to soften at the edges
Add the greens and grains:
Toss in spinach and cooked quinoa, stirring until the spinach collapses into everything else
Create the sauce:
Pour in the broth and let it simmer for 3 to 4 minutes—this step is what keeps the casserole from drying out in the oven
Assemble and cheese:
Transfer everything to your prepared baking dish, spread it evenly, and blanket the top with mozzarella and Parmesan
Bake covered:
Cover tightly with foil and bake for 25 minutes—this steams the squash until tender
Get the golden top:
Remove that foil and bake another 15 to 20 minutes until the cheese bubbles and turns golden brown in spots
The waiting game:
Let it rest for 5 minutes before serving—this helps everything set and makes serving so much easier
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Rinse produce, clean cookware, and fill pots smoothly with flexible spray options for everyday cooking.
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A hearty serving of Cozy Butternut Squash & Sausage Casserole on a rustic plate, garnished with fresh parsley and served alongside a green salad. Pin it
A hearty serving of Cozy Butternut Squash & Sausage Casserole on a rustic plate, garnished with fresh parsley and served alongside a green salad. | sonicpantry.com

My neighbor smelled this baking and knocked on my door with an empty Tupperware container. Now we have a standing arrangement—I make extra, she brings wine. Best trade I have ever made.

Make It Your Own

Sometimes I swap the quinoa for wild rice when I want something nuttier. Other times I add kale instead of spinach just because that is what I have in the fridge. The structure stays the same, but the ingredients shift with the seasons.

Timing Everything Right

I have learned to prep all my ingredients before I turn on any burners. The sausage cooks faster than you expect, and having everything measured and ready means you never scramble with hot grease splattering. Do your mise en place first—thank yourself later.

Leftovers Actually Get Better

This reheats beautifully for lunch the next day. The flavors have time to really marry and settle into each other. I pack individual portions in glass containers and they are the thing I look forward to most at work.

  • Sprinkle a little water before reheating to keep it from drying out
  • Add fresh cheese on top so it gets bubbly again
  • A fried egg on top turns leftovers into breakfast
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Freshly baked Cozy Butternut Squash & Sausage Casserole in a glass baking dish, showcasing golden bubbly cheese and colorful ingredients bubbling in the oven. Pin it
Freshly baked Cozy Butternut Squash & Sausage Casserole in a glass baking dish, showcasing golden bubbly cheese and colorful ingredients bubbling in the oven. | sonicpantry.com

This is the kind of dinner that makes winter feel like a gift instead of a punishment. Enjoy every warm, cheesy bite.

Frequently Asked Questions

Can I make this butternut squash casserole ahead of time?

Yes, you can assemble the entire dish up to 2 days in advance and refrigerate it. When ready to bake, add a few extra minutes to the baking time since it will be cold. The flavors actually meld together beautifully when made ahead.

What can I substitute for the quinoa?

Cooked rice or couscous work perfectly as alternatives to quinoa. Both provide a similar texture and will absorb the savory flavors just as well. Adjust cooking liquid slightly if needed.

How do I make this vegetarian?

Replace the Italian sausage with plant-based sausage crumbles or cannellini beans for protein. Use vegetable broth instead of chicken broth. The rest of the ingredients are naturally vegetarian-friendly.

Can I freeze this casserole?

Yes, this freezes well either before or after baking. If freezing unbaked, thaw completely in the refrigerator before baking as directed. For best results, wrap tightly and use within 3 months.

What wine pairs well with this dish?

A light red wine like Pinot Noir complements the savory sausage, while a crisp white such as Sauvignon Blanc contrasts nicely with the sweet butternut squash. Choose based on your preference for red or white.

How do I know when the squash is tender enough?

The squash should be easily pierced with a fork but not falling apart. After sautéing for 5-7 minutes, it should start softening. The final baking time ensures it becomes completely tender while absorbing all the seasoned flavors.

Butternut Squash & Sausage Casserole

Hearty squash and sausage bake with quinoa and melted cheese—perfect for cozy dinners.

Prep Time
20 Minutes
Cook Time
50 Minutes
Total Time
70 Minutes

Category: Everyday Mains

Difficulty: Easy

Cuisine: American

Yield: 6 servings

Dietary: Gluten-Free

Ingredients

Vegetables

01 1 medium butternut squash, peeled, seeded, and cut into 1-inch cubes
02 1 medium onion, diced
03 2 cloves garlic, minced
04 3 cups baby spinach
05 Fresh parsley, for garnish (optional)

Meats & Protein

01 1 pound Italian sausage (sweet or spicy), casing removed
02 1 cup cooked quinoa

Dairy

01 1 cup shredded mozzarella cheese
02 1/2 cup grated Parmesan cheese

Pantry & Spices

01 2 tablespoons olive oil
02 1 teaspoon dried thyme
03 1 teaspoon dried sage
04 1 teaspoon paprika
05 Salt and pepper, to taste

Liquids

01 1 cup chicken or vegetable broth

Instructions

Step 01

Prepare the Oven and Baking Dish: Preheat your oven to 375°F. Lightly grease a 9x13-inch baking dish with cooking spray or olive oil.

Step 02

Sauté the Onion: In a large skillet, heat olive oil over medium heat. Add the diced onion and cook until translucent, about 5 minutes.

Step 03

Add Garlic: Add minced garlic and cook for 1 minute, until fragrant.

Step 04

Brown the Sausage: Increase the heat slightly, add the Italian sausage, and cook until browned and cooked through, breaking it apart with a wooden spoon (about 7–10 minutes).

Step 05

Cook the Squash with Spices: Add the butternut squash to the skillet. Stir in dried thyme, dried sage, paprika, salt, and pepper. Cook for 5–7 minutes, stirring occasionally, until the squash starts to soften.

Step 06

Add Spinach and Quinoa: Add the baby spinach and cooked quinoa, stirring until the spinach wilts.

Step 07

Simmer with Broth: Pour in the chicken or vegetable broth and simmer for 3–4 minutes.

Step 08

Transfer to Baking Dish: Transfer the mixture to the prepared baking dish. Spread evenly and top with shredded mozzarella and grated Parmesan cheese.

Step 09

Bake Covered: Cover with aluminum foil and bake in the preheated oven for 25 minutes.

Step 10

Finish Uncovered: Remove the foil and bake for an additional 15–20 minutes, or until the cheese is bubbly and golden brown.

Step 11

Rest and Garnish: Remove from the oven and let cool for 5 minutes. Garnish with fresh parsley before serving.

Tools You'll Need

  • Large skillet
  • 9x13-inch baking dish
  • Chef's knife
  • Cutting board
  • Wooden spoon
  • Measuring cups and spoons
  • Aluminum foil

Allergy Information

Please check ingredients for potential allergens and consult a health professional if in doubt.
  • Contains dairy (mozzarella, Parmesan)
  • Contains potential gluten (in sausage or broth—use certified gluten-free versions if needed)
  • Contains possible sulfites in sausage
  • May contain celery (in some broths)
  • Always check ingredient labels if you have allergies or dietary restrictions

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 350
  • Total Fat: 19 g
  • Total Carbohydrate: 27 g
  • Protein: 20 g